Polynucleotides
(PDRN) Treatment in Zurich
Natural skin regeneration for a fresh, even complexion. Discover the innovative effect of polynucleotides – a biostimulating active ingredient that deeply intervenes in the skin structure and activates the natural regeneration process. At Metropolitan Clinic Zurich, we offer this modern method for targeted skin rejuvenation, wrinkle reduction, and improvement of skin quality.
What are Polynucleotides?
Polynucleotides (PDRN) are highly purified components of DNA, obtained from salmon – more precisely, from purified salmon sperm.
The extraction is carried out in an ethically responsible manner, without harm to the animal. Due to their regenerative properties, polynucleotides are successfully used in aesthetic medicine to stimulate cell repair, collagen production, and blood circulation.
Areas of Application for Polynucleotides
- Face (skin structure, elasticity, moisture)
- Eye area (fine lines, skin thinning)
- Neck and décolleté
- Scalp (for diffuse hair loss)
- Scars and skin irregularities
approx. 30 minutes
3–4 sessions at intervals of 2–3 weeks
little to none
gradual improvement with long-lasting effect with regular application

Scalp
Can help with diffuse hair loss
Face
Skin structure, elasticity & moisture
Eye area
Fine lines, skin thinning
Scars & Skin Irregularities
Neck and Décolleté

Scalp
Face
Eye area
Scars & Skin Irregularities
Neck and Décolleté
How the Treatment Works
Polynucleotides act directly at the cellular level and support the skin's natural regeneration processes. They activate cell renewal, promote microcirculation, and thus improve tissue supply. At the same time, the body's own collagen synthesis is stimulated, leading to a more stable, firmer skin structure. Fine lines can be smoothed, skin tone more even, and the skin can appear fresher overall. A significant advantage is the intensive deep hydration, without building volume or altering facial features. Naturalness is fully preserved.
The treatment is carried out using finely dosed microinjections into the middle skin layer as part of a mesotherapy technique. The active ingredient is evenly distributed and specifically introduced where skin regeneration is to be supported.
- acts at the cellular level
- stimulates regeneration and collagen formation
- improves skin quality and skin tone
- smoothes fine lines without volume effect
- intensive deep hydration
- gentle microinjections (mesotherapy)
- suitable for face, neck, and décolleté






